Mangesh Bhutkar — новинки

Plant and plant products are being used as a source of medicine since long. Natural antioxidants that are present in plants and herbs are responsible for inhibiting or preventing the deleterious consequences of oxidative stress. Many Indian medicinal plants are considered to be potential sources of antioxidant compounds. However, the majority of rich diversity of these medicinal plants is yet to be significantly evaluated for such properties. Considering an increased quest to obtain natural antioxidants with broad-spectrum actions and potential antioxidant activity, this book highlights the various methods to assess antioxidant activity of medicinal plants. It also attempts to evaluate the antioxidant activity of some commonly used indigenous plants using different systems of in-vitro assays to provide scientific evidence about their antioxidant property and explore an antioxidant with promising activity. Our results further support the view that some traditionally used Indian medicinal plants are promising sources of potential antioxidants.

There are many clinical and experimental evidences indicating the involvement of oxidative stress in pathogenesis of diabetes mellitus and its complications. Increased oxidative stress is due to excessive reactive oxygen species generation due to persistent hyperglycemia and a sharp reduction of antioxidants defenses and the tissue antioxidant status. An imbalance between oxidative stress and antioxidative defense mechanisms in diabetics can result in cell and tissue damage and accelerate diabetic complications. There is mounting evidence that a general increase in antioxidant status achieved by dietary supplementation can help to diminish oxidative stress in diabetics and profoundly contribute to reduce the severity of the disease. Plant antioxidants by virtue of their antioxidant activity, may exert beneficial implications for diabetes management. This book highlights the various methods to assess antioxidant activity of medicinal plants. It also contributes to ascertain the utility of plant antioxidants to markedly complement the anti- diabetic therapies by reducing the oxidative stress in diabetics and its associated complications.

Until the advent of soft gelatin capsules there were no significant changes in capsule manufacturing. Then it became a trend for liquid substances to be filled into soft gelatin capsules and hard gelatin capsules were allocated for dry fill only. However, the filling of molten or thixotropic liquids into hard gelatin capsules is more advantageous when compared to liquid filled soft capsules and may be employed to overcome a number of problems which are frequently associated with the development and manufacture of conventional capsules. This book highlights the basis for development of liquid filled capsule dosage form and focuses light on utility of capsule shells made up from gelatin and Chitosan for liquid filling. It also contributes to ascertain that hard capsules may be used for delivery of Vitamin E and may act as a suitable alternative for soft gelatin capsules. The findings are fruitful for the researchers to compare the utility of hard capsules for delivery of liquid drugs with the soft gelatin capsules.