S. S. Rajan — новинки

Gouty arthritis is one of the major problems whose prevalence has doubled in the past decades. Studies have estimated that over 20 million people suffer from gout every year. Allopurinol, the major drug used in the treatment has very poor bioavailability and results in many severe side effects. This book addresses this problem as it has large social implications on the society. One of the recent approaches to explore new pharmaceutical drug is the design of the cocrystals. It has an added advantage that as both the compounds are already approved by the FDA no more drug trial is necessary and hence can be brought to the market in a short period. This work deals with the synthesis and preliminary characterization of cocrystals of Allopurinol. The present work has been carried out over a period of seven months at Sri Sathya Sai Institute of Higher Learning, Prasanthinilayam, India.

The work describes the isolation of some tetranortriterpenoids from meliaceae family along with their characterization using NMR, Single crystal X-ray Diffraction studies etc. Chemical modifications of some selected molecules have been reported and the antifeedant activity of all molecules have been assayed against spodoptura litura.Finally, some insilico studies were carried out, which pointed to some molecular parameters (descriptors) that might be responsible for the antifeedant activity of these molecules